The peroxisomes strike BAK: Regulation of peroxisome integrity by the Bcl-2 family
نویسندگان
چکیده
Within the mitochondrial pathway of apoptosis, VDAC2 controls both the localization and proapoptotic activity of BAK. In this issue, Hosoi et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201605002) find that loss of VDAC2 diverts BAK into peroxisome membranes, revealing the ability of BAK to control peroxisome membrane integrity and the release of soluble peroxisomal matrix proteins.
منابع مشابه
The VDAC2–BAK axis regulates peroxisomal membrane permeability
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